The Biology Book: From the Origin of Life to Epigenetics, 250 Milestones in the History of Biology (2015)

REM Sleep

Henri Piéron (1881–1964), Nathaniel Kleitman (1895–1999), Eugene Aserinsky (1921–1998)

1953

“To sleep, perchance to dream.” Sleep was long believed to be a period of uninterrupted quiescence, when the body slowed down. In 1913, the French psychologist Henri Piéron authored the book Le probleme physiologique du sommeil, the first attempt to examine sleep from a physiological perspective. Piéron also sought evidence that a chemical factor (“hypnotoxin”) accumulates in the brain during waking periods and eventually induces sleep.

During the 1920s, the Russian-born American physiologist Nathaniel Kleitman established the world’s first sleep laboratory at the University of Chicago and exclusively dedicated his long career to sleep research; at the time, sleep research appeared on no one’s scientific radar screen. Kleitman’s Sleep and Wakefulness (1939) was the first major text on this topic and is still judged a classic; in it, he proposed that sleep consisted of a rest-activity cycle. He also frequently served as his own subject, and on one occasion, remained awake for 180 consecutive hours to study the effects of sleep deprivation.

In 1953, Kleitman’s graduate student Eugene Aserinsky began studying attention in children and noted that eye closure was associated with lapses in attention; his first subject was his eight-year-old son. Aserinsky recorded children’s eyelid movements electronically and monitored brainwaves using an electroencephalogram (EEG). The resulting brain tracings appeared to be associated with dreaming. Aserinsky continued his studies, recording the EEG and eye movements of sleeping adults and observed that, several times during the night, their eyes darted back and forth. These were named rapid eye movements or REM, and their appearance correlated with episodes of dreaming. (Ironically, Aserinsky died in 1998 when his car hit a tree, after he fell asleep.)

Sleep is not a unitary and prolonged state of quiescence. Rather, it consists of distinct phases, with REM consuming 20–25 percent of total sleep, some 90 to 120 minutes, divided over 4 to 5 periods; more than 80 percent of newborn sleep is in REM. Its biological function remains the subject of theorizing—perhaps its function is to consolidate memories or for the central nervous system development of newborns—but we do know that loss of REM results in significant physiological and behavioral abnormalities.

SEE ALSO: Circadian Rhythms (1729).

While REM represents only 20-25 percent of an adult’s sleep, it represents up to 80 percent of a newborn’s sleep. A dreaming infant is shown in this 1928 painting by Hermann Knopf (1870–1928).